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Peautrier Microabscesses - T-cells aggregate in the skin -- T-cell lymphoma (Just memorize for the Boards)
Burkitt Lymphoma t(8;14) -- vacuoles, starry night; associated with EBV
Sickle cell anemia -- in kids, RBCs get sequestered in spleen, splenomegaly, autoinfarction, then spleen shrinks as they go into adulthood; risk of aplastic crisis if Folate deficiency or infected with Parvo B19; Tx by hydroxyurea
Normal blood smear
Iron deficiency anemia
Megaloblastic anemia - due to B12 deficiency, folate deficiency, myelodysplasia, or anything that inhibits DNA synthesis (chemotherapy, etc)
Thrombotic thrombocytopenic purpura (TTP) - microangiopathic hemolytic anemia; schistocytes; inhibition of ADAMTS13; Tx by plasma exchange
Spherocytes - hereditary spherocytosis; or warm autoimmune hemolytic anemia; splenomegaly; risk of aplastic crisis if infected with Parvo B19
Nucleated RBC - note red/pink color of cytoplasm. This may look like plasma cell, but plasma cells rarely appear in PBS.
Essential Thrombocytosis (ET) - mutant JAK2; ^ platelets but dysfunctional, so ->bleeding ; ^ megakaryocytes; **diagnosis by exclusion..**
Hairy cell leukemia - B-cell leukemia; generally good prognosis (Tx by Cladrabine) TRAP test; *** NO LYMPHADENOPATHY**;
Auer Rod --> AML Acute Myelogenous Leukemia -- Acquired mutation arrests marrow stem cell maturation at various stages
Acute leukemia - abundance of blast cells (immature cells)
Bite cell - splenic phagocytes bite out clump of Heinz bodies (oxidized/denatured Hb) that form as a result of G6PD deficiency
Rouleux - forming in patient with Multiple myeloma (clonal proliferation of plasma cells); hypercalcemia; lytic bone lesions; M-spike (due to homogeneous Ig production); Bence-Jones proteins (toxic to renal tubules); Tx by autologus BMT, thalidomide, bort
(bcl-2 stain)
Germinal center stains positive for BCL-2, so this is a malignant lymphoma
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